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Effect of surgical factors on the augmentation of cement-injectable cannulated pedicle screw fixation

Haolin Sun, Chun Liu, Shunlun Chen, Yanjie Bai, Huilin Yang, Chunde Li, Lei Yang

《医学前沿（英文）》 2019年 第13卷 第5期   页码 590-601 doi: 10.1007/s11684-019-0710-z

摘要： Bone cement-augmented pedicle screw system demonstrates great efficacy in spinal disease treatments. However, the intrinsic drawbacks associated with clinically used polymethylmethacrylate (PMMA) cement demands for new bone cement formulations. On the basis of our previous studies, a novel injectable and biodegradable calcium phosphate-based nanocomposite (CPN) for the augmentation of pedicle screw fixation was systematically evaluated for its surgical feasibility and biomechanical performance by simulated and animal osteoporotic bone models, and the results were compared with those of clinical PMMA cement. ASTM-standard solid foam and open-cell foam models and decalcified sheep vertebra models were employed to evaluate the augmentation effects of CPN on bone tissue and on the cement-injected cannulated pedicle screws (CICPs) placed in osteoporotic bone. Surgical factors in CICPs application, such as injection force, tapping technique, screw diameter, and pedicle screw loosening scenarios, were studied in comparison with those in PMMA. When directly injected to the solid foam model, CPN revealed an identical augmentation effect to that of PMMA, as shown by the similar compressive strengths (0.73±0.04 MPa for CPN group vs. 0.79±0.02 MPa for PMMA group). The average injection force of CPN at approximately 40–50 N was higher than that of PMMA at approximately 20 N. Although both values are acceptable to surgeons, CPN revealed a more consistent injection force pattern than did PMMA. The dispersing and anti-pullout ability of CPN were not affected by the surgical factors of tapping technique and screw diameter. The axial pullout strength of CPN evaluated by the decalcified sheep vertebra model revealed a similar augmentation level as that of PMMA (1351.6±324.2 N for CPN vs. 1459.7±304.4 N for PMMA). The promising results of CPN clearly suggest its potential for replacing PMMA in CICPs augmentation application and the benefits of further study and development for clinical uses.

关键词： bone cement     pedicle screw     degenerative spinal diseases     calcium phosphate     injectable    

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Current advances for bone regeneration based on tissue engineering strategies

Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian

《医学前沿（英文）》 2019年 第13卷 第2期   页码 160-188 doi: 10.1007/s11684-018-0629-9

摘要： Bone tissue engineering (BTE) is a rapidly developing strategy for repairing critical-sized bone defects to address the unmet need for bone augmentation and skeletal repair. Effective therapies for bone regeneration primarily require the coordinated combination of innovative scaffolds, seed cells, and biological factors. However, current techniques in bone tissue engineering have not yet reached valid translation into clinical applications because of several limitations, such as weaker osteogenic differentiation, inadequate vascularization of scaffolds, and inefficient growth factor delivery. Therefore, further standardized protocols and innovative measures are required to overcome these shortcomings and facilitate the clinical application of these techniques to enhance bone regeneration. Given the deficiency of comprehensive studies in the development in BTE, our review systematically introduces the new types of biomimetic and bifunctional scaffolds. We describe the cell sources, biology of seed cells, growth factors, vascular development, and the interactions of relevant molecules. Furthermore, we discuss the challenges and perspectives that may propel the direction of future clinical delivery in bone regeneration.

关键词： bone tissue engineering     stem cell     bone scaffold     growth factor     bone regeneration    

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Extending blending proportions of ordinary Portland cement and calcium sulfoaluminate cement blends:

《结构与土木工程前沿（英文）》 2021年 第15卷 第5期   页码 1249-1260 doi: 10.1007/s11709-021-0770-4

摘要： This study extended blending proportion range of ordinary Portland cement (OPC) and calcium sulfoaluminate (CSA) cement blends, and investigated effects of proportions on setting time, workability, and strength development of OPC-CSA blend-based mixtures. Thermogravimetric analysis (TGA) and X-ray diffraction (XRD) were conducted to help understand the performance of OPC-CSA blend-based mixtures. The setting time of the OPC-CSA blends was extended, and the workability was improved with increase of OPC content. Although the early-age strength decreased with increase of OPC content, the strength development was still very fast when the OPC content was lower than 60% due to the rapid formation and accumulation of ettringite. At 2 h, the OPC-CSA blend-based mortars with OPC contents of 0%, 20%, 40%, and 60% achieved the unconfined compressive strength (UCS) of 17.5, 13.9, 9.6, and 5.0 MPa, respectively. The OPC content had a negligible influence on long-term strength. At 90 d, the average UCS of the OPC-CSA blend-based mortars was 39.2 ± 1.7 MPa.

关键词： calcium sulfoaluminate cement     cement blends     hydration reaction     setting     workability     compressive strength    

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ITZ microstructure, thickness, porosity and its relation with compressive and flexural strength of cementmortar; influence of cement fineness and water/cement ratio

《结构与土木工程前沿（英文）》 2022年 第16卷 第2期   页码 191-201 doi: 10.1007/s11709-021-0792-y

摘要： A new insight into the interfacial transition zone (ITZ) in cement mortar specimens (CMSs) that is influenced by cement fineness is reported. The importance of cement fineness in ITZ characterizations such as morphology and thickness is elucidated by backscattered electron images and by consequences to the compressive (Fc) and flexural strength (Ff), and porosity at various water/cement ratios. The findings indicate that by increasing the cement fineness the calcium silicate hydrate formation in the ITZ is favored and that this can refine the pore structures and create a denser and more homogeneous microstructure. By increasing cement fineness by about 25% of, the ITZ thickness of CMSs was reduced by about 30% and Fc was increased by 7%–52% and Ff by 19%–40%. These findings illustrate that the influence of ITZ features on the mechanical strength of CMSs is mostly related to the cement fineness and ITZ microstructure.

关键词： cement fineness     interfacial transition zone     compressive and flexural strength    

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FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

《医学前沿（英文）》 2022年 第16卷 第6期   页码 896-908 doi: 10.1007/s11684-022-0944-z

摘要： Fibroblast growth factor 13 (FGF13) is aberrantly expressed in multiple cancer types, suggesting its essential role in tumorigenesis. Hence, we aimed to explore its definite role in the development of acute myeloid leukemia (AML) and emphasize its associations with bone marrow niches. Results showed that FGF13 was lowly expressed in patients with AML and that its elevated expression was related to prolonged overall survival (OS). Univariate and multivariate Cox regression analyses identified FGF13 as an independent prognostic factor. A prognostic nomogram integrating FGF13 and clinicopathologic variables was constructed to predict 1-, 3-, and 5-year OS. Gene mutation and functional analyses indicated that FGF13 was not associated with AML driver mutations but was related to bone marrow niches. As for immunity, FGF13 was remarkably associated with T cell count, immune checkpoint genes, and cytokines. In addition, FGF13 overexpression substantially inhibited the growth and significantly induced the early apoptosis of AML cells. The xenograft study indicated that FGF13 overexpression prolonged the survival of recipient mice. Overall, FGF13 could serve as an independent prognostic factor for AML, and it was closely related to the bone marrow microenvironment.

关键词： acute myeloid leukemia     FGF13     prognosis     immune-related genes     bone marrow niches    

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Study of bond strength between various grade of Ordinary Portland Cement (OPC) and Portland PozzolaneCement (PPC) mixes and different diameter of TMT bars by using pullout test

A D POFALE, S P WANJARI

《结构与土木工程前沿（英文）》 2013年 第7卷 第1期   页码 39-45 doi: 10.1007/s11709-013-0193-y

摘要： Since last two decades, the Portland Pozzolane Cement (PPC) is extensively used in structural concrete. But, till to date, a few literature is available on bond strength of concrete using PPC mixes. There are many literatures available on bond strength of concrete mixes using Ordinary Portland Cement (OPC). Hence, a comparative study was conducted on bond strength between OPC and PPC mixes. In the present investigation, total 24 samples consisting of M20, M35 and M50 grades of concrete and 16 and 25 mm diameter of TMT bar were tested for 7 and 28 days. The pullout bond test was conducted on each specimen as per IS: 2770-1967/1997 [1] and the results were observed at 0.25 mm slip at loaded end called as critical bond stress and at maximum bond load called as maximum bond stress. It was observed that the critical bond strength of PPC mixes is 10% higher than OPC mixes. Whereas, marginal improvement was noticed in maximum bond strength of PPC mixes. Hence, based on these findings, it could be concluded that development length for PPC mixes could be reduced by 10% as compared with same grade of OPC mixes.

关键词： bond strength     Portland Pozzolane Cement (PPC) concrete     Ordinary Portland Cement (OPC) concrete     bond between concrete and steel     pullout test     development length    

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Autologous bone marrow stem cell transplantation for the treatment of ulcerative colitis complicated

null

《医学前沿（英文）》 2016年 第10卷 第4期   页码 522-526 doi: 10.1007/s11684-016-0485-4

摘要：

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with continuous or recurrent symptoms. A 42-year-old male patient with intermittent diarrhea accompanied by bloody mucopurulent stools was admitted to our hospital. The diagnosis of UC was confirmed by a combination of laboratory examination, colonoscopy, and histological assay. The patient developed herpes zoster in the hospital, which challenged traditional treatments. Therefore, we performed an autologous bone marrow cells to modulate the immune system with his permission. Autologous bone marrow mononuclear cells were collected and injected locally into the bowel mucosa, and subsequently injected systemically through a peripheral vein. After the patient underwent auto bone marrow mononuclear cells transplantations twice, the patient’s symptoms were alleviated. Furthermore, he recovered from hematochezia, and his hypersensitive C reactive protein decreased. Colonoscopy results showed reduced lesions and decreased areas with bleeding and edema in the sigmoid colon and rectum. No recurrence occurred in the subsequent two years, but long-time monitoring is still necessary for the prophylaxis of colorectal cancer.

关键词： autograft     bone marrow stem cells     ulcerative colitis     cell therapy    

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Machinability of ultrasonic vibration-assisted micro-grinding in biological bone using nanolubricant

《机械工程前沿（英文）》 2023年 第18卷 第1期 doi: 10.1007/s11465-022-0717-z

摘要： Bone grinding is an essential and vital procedure in most surgical operations. Currently, the insufficient cooling capacity of dry grinding, poor visibility of drip irrigation surgery area, and large grinding force leading to high grinding temperature are the technical bottlenecks of micro-grinding. A new micro-grinding process called ultrasonic vibration-assisted nanoparticle jet mist cooling (U-NJMC) is innovatively proposed to solve the technical problem. It combines the advantages of ultrasonic vibration (UV) and nanoparticle jet mist cooling (NJMC). Notwithstanding, the combined effect of multi parameter collaborative of U-NJMC on cooling has not been investigated. The grinding force, friction coefficient, specific grinding energy, and grinding temperature under dry, drip irrigation, UV, minimum quantity lubrication (MQL), NJMC, and U-NJMC micro-grinding were compared and analyzed. Results showed that the minimum normal grinding force and tangential grinding force of U-NJMC micro-grinding were 1.39 and 0.32 N, which were 75.1% and 82.9% less than those in dry grinding, respectively. The minimum friction coefficient and specific grinding energy were achieved using U-NJMC. Compared with dry, drip, UV, MQL, and NJMC grinding, the friction coefficient of U-NJMC was decreased by 31.3%, 17.0%, 19.0%, 9.8%, and 12.5%, respectively, and the specific grinding energy was decreased by 83.0%, 72.7%, 77.8%, 52.3%, and 64.7%, respectively. Compared with UV or NJMC alone, the grinding temperature of U-NJMC was decreased by 33.5% and 10.0%, respectively. These results showed that U-NJMC provides a novel approach for clinical surgical micro-grinding of biological bone.

关键词： micro-grinding     biological bone     ultrasonic vibration (UV)     nanoparticle jet mist cooling (NJMC)     grinding force     grinding temperature    

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Hybrid polymer biomaterials for bone tissue regeneration

Bo Lei, Baolin Guo, Kunal J. Rambhia, Peter X. Ma

《医学前沿（英文）》 2019年 第13卷 第2期   页码 189-201 doi: 10.1007/s11684-018-0664-6

摘要： Native tissues possess unparalleled physiochemical and biological functions, which can be attributed to their hybrid polymer composition and intrinsic bioactivity. However, there are also various concerns or limitations over the use of natural materials derived from animals or cadavers, including the potential immunogenicity, pathogen transmission, batch to batch consistence and mismatch in properties for various applications. Therefore, there is an increasing interest in developing degradable hybrid polymer biomaterials with controlled properties for highly efficient biomedical applications. There have been efforts to mimic the extracellular protein structure such as nanofibrous and composite scaffolds, to functionalize scaffold surface for improved cellular interaction, to incorporate controlled biomolecule release capacity to impart biological signaling, and to vary physical properties of scaffolds to regulate cellular behavior. In this review, we highlight the design and synthesis of degradable hybrid polymer biomaterials and focus on recent developments in osteoconductive, elastomeric, photoluminescent and electroactive hybrid polymers. The review further exemplifies their applications for bone tissue regeneration.

关键词： hybrid polymer     bone regeneration     tissue engineering     biomaterials    

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Autogenous healing mechanism of cement-based materials

《结构与土木工程前沿（英文）》   页码 948-963 doi: 10.1007/s11709-023-0960-3

摘要： Autogenous self-healing is the innate and fundamental repair capability of cement-based materials for healing cracks. Many researchers have investigated factors that influence autogenous healing. However, systematic research on the autogenous healing mechanism of cement-based materials is lacking. The healing process mainly involves a chemical process, including further hydration of unhydrated cement and carbonation of calcium oxide and calcium hydroxide. Hence, the autogenous healing process is influenced by the material constituents of the cement composite and the ambient environment. In this study, different factors influencing the healing process of cement-based materials were investigated. Scanning electron microscopy and optical microscopy were used to examine the autogenous healing mechanism, and the maximum healing capacity was assessed. Furthermore, detailed theoretical analysis and quantitative detection of autogenous healing were conducted. This study provides a valuable reference for developing an improved healing technique for cement-based composites.

关键词： autogenous healing     cement-based materials     healing mechanism     aggregation effect    

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Research review of the cement sand and gravel (CSG) dam

Xin CAI, Yingli WU, Xingwen GUO, Yu MING

《结构与土木工程前沿（英文）》 2012年 第6卷 第1期   页码 19-24 doi: 10.1007/s11709-012-0145-y

摘要： The cement sand and gravel (CSG) dam is a new style of dam that owes the advantages both of the concrete faced rock-fill dam (CRFD) and roller compacted concrete (RCC) gravity dam, because of which it has attracted much attention of experts home and abroad. At present, some researches on physic-mechanical property of CSG material and work behavior of CSG dam have been done. This paper introduces the development and characteristics of CSG dam systematically, and summarizes the progress of the study on basic tests, constitutive relation of CSG material and numerical analysis of CSG dam, in addition, indicates research and application aspect of the dam.

关键词： cement sand and gravel (CSG) dam     cement sand and gravel (CSG) material     research review    

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Experimental study and field application of calcium sulfoaluminate cement for rapid repair of concrete

Yanhua GUAN, Ying GAO, Renjuan SUN, Moon C. WON, Zhi GE

《结构与土木工程前沿（英文）》 2017年 第11卷 第3期   页码 338-345 doi: 10.1007/s11709-017-0411-0

摘要： The fast-track repair of deteriorated concrete pavement requires materials that can be placed, cured, and opened to the traffic in a short period. Type III cement and Calcium Sulfoaluminate (CSA) cement are the most commonly used fast-setting hydraulic cement (FSHC). In this study, the properties of Type III and CSA cement concrete, including compressive strength, coefficient of thermal expansion (CTE) and shrinkage were evaluated. The test results indicate that compressive strength of FSHC concrete increased rapidly at the early age. CSA cement concrete had higher early-age and long term strength. The shrinkage of CSA cement concrete was lower than that of Type III cement concrete. Both CSA and Type III cement concrete had similar CTE values. Based on the laboratory results, the CSA cement was selected as the partial-depth rapid repair material for a distressed continuously reinforced concrete pavement. The data collected during and after the repair show that the CSA cement concrete had good short-term and long-term performances and, therefore, was suitable for the rapid repair of concrete pavement.

关键词： Calcium Sulfoaluminate (CSA) cement     Type III cement     coefficient of thermal expansion (CTE)     shrinkage     rapid repair    

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Progress of three-dimensional macroporous bioactive glass for bone regeneration

Lijun JI, Yunfeng SI, Ailing LI, Wenjun WANG, Dong QIU, Aiping ZHU

《化学科学与工程前沿（英文）》 2012年 第6卷 第4期   页码 470-483 doi: 10.1007/s11705-012-1217-1

摘要： Bioactive glasses (BGs) are ideal materials for macroporous scaffolds due to their excellent osteoconductive, osteoinductive, biocompatible and biodegradable properties, and their high bone bonding rates. Macroporous scaffolds made from BGs are in high demand for bone regeneration because they can stimulate vascularized bone ingrowth and they enhance bonding between scaffolds and surrounding tissues. Engineering BG/biopolymers (BP) composites or hybrids may be a good way to prepare macroporous scaffolds with excellent properties. This paper summarizes the progress in the past few years in preparing three-dimensional macroporous BG and BG/BP scaffolds for bone regeneration. Since the brittleness of BGs is a major problem in developing macroporous scaffolds and this limits their use in load bearing applications, the mechanical properties of macroporous scaffolds are particularly emphasized in this review.

关键词： bioactive glass     biopolymer     bone regeneration     macroporous scaffolds     tissue engineering    

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Thermochemical pretreatment of meat and bone meal and its effect on methane production

Guangxue WU , Zhenhu HU , Mark G. HEALY , Xinmin ZHAN ,

《环境科学与工程前沿（英文）》 2009年 第3卷 第3期   页码 300-306 doi: 10.1007/s11783-009-0031-6

摘要： Since the solubilization of meat and bone meal (MBM) is a prerequisite in many MBM disposal approaches, enhancement of the solubilization by means of thermochemical pretreatment was investigated in this study at two temperatures (55°C and 131°C) and six sodium hydroxide (NaOH) concentrations (0, 1.25, 2.5, 5, 10 and 20g/L). The MBM volatile solid (VS) reduction ratio was up to 66% and 70% at 55°C and 131°C, respectively. At the same temperature, the VS reduction ratio increased with the increase in the dosage of NaOH. The study on the methane (CH) production potential of pretreated MBM shows that the addition of NaOH at 55°C did not cause the inhibition of the succeeding CH production process. However, CH production was inhibited by the addition of NaOH at 131°C. The CH production potential was in the range of 389 to 503mL CH/g VS MBM and 464 to 555mL CH/g VS MBM at 55°C and 131°C, respectively.

关键词： thermochemical pretreatment     meat and bone meal     solid reduction     solid solubilization     methane production potential    

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Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

《医学前沿（英文）》 2022年 第16卷 第4期   页码 551-573 doi: 10.1007/s11684-022-0928-z

摘要： Patients with hepatocellular carcinoma (HCC) and bone metastasis (BM) suffer from greatly reduced life quality and a dismal prognosis. However, BM in HCC has long been overlooked possibly due to its relatively low prevalence in previous decades. To date, no consensus or guidelines have been reached or formulated for the prevention and management of HCC BM. Our narrative review manifests the increasing incidence of HCC BM to sound the alarm for additional attention. The risk factors, diagnosis, prognosis, and therapeutic approaches of HCC BM are detailed to provide a panoramic view of this disease to clinicians and specialists. We further delineate an informative cancer bone metastatic cascade based on evidence from recent studies and point out the main factors responsible for the tumor-associated disruption of bone homeostasis and the formation of skeletal cancer lesions. We also present the advances in the pathological and molecular mechanisms of HCC BM to shed light on translational opportunities. Dilemmas and challenges in the treatment and investigation of HCC BM are outlined and discussed to encourage further endeavors in the exploration of underlying pathogenic and molecular mechanisms, as well as the development of novel effective therapies for HCC patients with BM.

关键词： HCC     bone     osteotropism     clinical     basic researches     advances    

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标题 作者 时间 类型 操作

Effect of surgical factors on the augmentation of cement-injectable cannulated pedicle screw fixation

Haolin Sun, Chun Liu, Shunlun Chen, Yanjie Bai, Huilin Yang, Chunde Li, Lei Yang

期刊论文

Current advances for bone regeneration based on tissue engineering strategies

Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian

期刊论文

Extending blending proportions of ordinary Portland cement and calcium sulfoaluminate cement blends:

期刊论文

ITZ microstructure, thickness, porosity and its relation with compressive and flexural strength of cementmortar; influence of cement fineness and water/cement ratio

期刊论文

FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

期刊论文

Study of bond strength between various grade of Ordinary Portland Cement (OPC) and Portland PozzolaneCement (PPC) mixes and different diameter of TMT bars by using pullout test

A D POFALE, S P WANJARI

期刊论文

Autologous bone marrow stem cell transplantation for the treatment of ulcerative colitis complicated

null

期刊论文

Machinability of ultrasonic vibration-assisted micro-grinding in biological bone using nanolubricant

期刊论文

Hybrid polymer biomaterials for bone tissue regeneration

Bo Lei, Baolin Guo, Kunal J. Rambhia, Peter X. Ma

期刊论文

Autogenous healing mechanism of cement-based materials

期刊论文

Research review of the cement sand and gravel (CSG) dam

Xin CAI, Yingli WU, Xingwen GUO, Yu MING

期刊论文

Experimental study and field application of calcium sulfoaluminate cement for rapid repair of concrete

Yanhua GUAN, Ying GAO, Renjuan SUN, Moon C. WON, Zhi GE

期刊论文

Progress of three-dimensional macroporous bioactive glass for bone regeneration

Lijun JI, Yunfeng SI, Ailing LI, Wenjun WANG, Dong QIU, Aiping ZHU

期刊论文

Thermochemical pretreatment of meat and bone meal and its effect on methane production

Guangxue WU , Zhenhu HU , Mark G. HEALY , Xinmin ZHAN ,

期刊论文

Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

期刊论文